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Saturday, May 9, 2020 | History

2 edition of structure of Semliki Forest virus. found in the catalog.

structure of Semliki Forest virus.

Carl-Henrik von Bonsdorff

structure of Semliki Forest virus.

by Carl-Henrik von Bonsdorff

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  • 34 Currently reading

Published by Societas Scientiarum Fennica in Helsinki .
Written in English

    Subjects:
  • Semliki Forest virus.

  • Edition Notes

    SeriesCommentationes biologicae, 74
    The Physical Object
    Pagination53 p. :
    Number of Pages53
    ID Numbers
    Open LibraryOL21446375M

    The helical nature of this virus is quite clear in negative staining electron micrographs since the virus forms a rigid rod-like structure. In enveloped, helically symmetrical viruses (e.g. influenza virus, rabies virus), the capsid is more flexible (and longer) and appears in negative stains rather like a . pertinent to the virus–cell interaction. Replication pro-cesses of viruses of the family Togaviridae have been most extensively studied for the alphaviruses, Sindbis virus (SINV) and Semliki Forest virus (SFV), and extrapolated to the other family members. Virus Attachment, Entry, and Uncoating s

    Semliki Forest virus (SFV) is a positive-strand RNA virus and, similar to the related alphaviruses, like Sindbis virus, has potential as a gene therapy vector and an oncolytic virotherapy agent, but this potential is limited by the neurovirulence of these alphaviruses. Understanding alphavirus molecular biology, pathogenesis and host interactions are key areas of research that have applications not only in disease prevention but also in permitting the exploitation of certain alphaviruses, e.g. Semliki Forest virus, as efficient gene therapy and/or vaccine delivery vehicles.

    A knowledge resource to understand virus diversity. Human viruses and associated pathologies The table below displays the list of human viral pathogens, with transmission and general facts about associated pathologies. (See human viruses by Baltimore classification). A fatal case of human encephalitis has been observed for which our results indicate that Semliki Forest virus (SFV) was the etiologic agent. This is surprising in view of the fact that this virus, which has been widely studied, was believed to be one of the arboviruses nonpathogenic for man. Described are the clinical course, the virological examinations performed, and the histopathological.


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Structure of Semliki Forest virus by Carl-Henrik von Bonsdorff Download PDF EPUB FB2

The second class of fusion proteins was identified when the X-ray prefusion structure of the ectodomain of the fusion protein E1 of Semliki Forest virus (SFV) (Lescar et al., ), an alphavirus, was shown to have a remarkably similar secondary and tertiary structure to that of the fusion protein E of tick-borne encephalitis virus (TBEV) (Rey.

The structure of Semliki Forest virus. [Carl-Henrik von Bonsdorff] Home. WorldCat Home About WorldCat Help. Search.

Search for Library Items Search for Lists Search for Book: All Authors / Contributors: Carl-Henrik von Bonsdorff. Find more information about: ISBN: OCLC Number: The structure of the Semliki Forest virus revealed a structure that is similar to that of flaviviral glycoprotein E, with three structural domains in the same primary sequence arrangement.

The E2 glycoprotein functions to interact with the nucleocapsid through its cytoplasmic domain, while its ectodomain is responsible for binding a cellular Family: Togaviridae. Fu-Dong Shi, Richard M.

Ransohoff, in Natural Killer Cells, Semliki Forest virus. Semliki Forest virus (SFV) is a positive-stranded RNA virus (Atkins et al., ; Smithburn and Haddow, ).Infection of C57BL/6 mice with SFV leads to pronounced CNS cellular infiltration and apoptosis of microglial and neuronal cells (Alsharifi et al., ).In this model, NK cells and, to a lesser.

We have studied the low-pH-mediated fusion process of the alphavirus Semliki Forest virus (SFV). The spike protein of SFV is composed of three copies of the protein heterodimer Structure of Semliki Forest virus.

book. This structure is resistant to solubilization in mild detergents such as Nonidet P (NP40).Cited by: Structure of an Enveloped Virus: the Semliki Forest Virus Amongst the wide variety of viruses, some have rather simple spherical structures.

Examples are the rhinovirus, which causes the common cold, and the poliovirus, the agent causing poliomyelitis.

The Semliki Forest virus is a positive-stranded RNA virus with a genome of approximat base pairs which encodes nine proteins. The 5’ two thirds of the genome encode four non-structural proteins concerned with RNA synthesis and the structural proteins are encoded in the 3’ third. The structure of the Sindbis virus (SINV) (the type virus) core protein (SCP) was previously determined and found to have a chymotrypsin-like structure.

SCP is a serine proteinase which cleaves itself from a polyprotein. Semliki Forest virus (SFV) is among the most distantly related alphaviruses to by: Alphavirus particles are roughly spherical, with three principal substructures—an outer glycoprotein shell, a lipid bilayer, and an RNA-containing core (nucleocapsid).

The radial organization of these components is summarized in Fig. The most extensive structural studies have been carried out on Sindbis virus and Semliki Forest virus (SFV). Cross-species viral transmission subjects parent and progeny alphaviruses to differential post-translational processing of viral envelope glycoproteins.

Alphavirus biogenesis has been extensively studied, and the Semliki Forest virus E1 and E2 glycoproteins have been shown to exhibit differing degrees of processing of N-linked glycans. However the composition of these glycans, including that. Semliki Forest virus.

PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES. SECTION I - INFECTIOUS AGENT. NAME: Semliki Forest Virus. SYNONYM OR CROSS REFERENCE: SFV (), Old World Alphavirus (4), Semliki Forest Fever (5) CHARACTERISTICS: Family Togaviridae, Genus Alphavirus (6, 7).

Virus Particle Semliki Forest Virus Rift Valley Fever Virus Viral Capsid Protein Virion Structure These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Semliki Forest Virus infection is an uncharacterized nonfatal disease, probably mildly febrile and of short duration, in tropical Africa. Mayaro virus disease of the New World tropics is characterized by fever, headache, photo­phobia, conjunctival injection, generalized aches and pains, occasional nausea, and slight icterus with mild leukopenia for a period averaging three days.

Semliki Forest virus (SFV), first isolated from Aedes abnormalis mosquitoes in the Semliki Forest of Uganda (Manwaring, ), is naturally found in sub-Saharan Africa and is principally spread by. Abstract The effects of increasing concentrations of sodium deoxycholate on Semliki Forest have been studied.

Sodium deoxycholate begins to bind to the virus at less than mM free equilibrium concentration and causes lysis of the viral membrane at +/- mM free equilibrium concentration when +/- - mol of sodium deoxycholate are bound per mol of virus.

Semliki Forest virus (SFV) vectors have been developed to provide a convenient system to express protein‐encoding sequences in virtually any animal cell.

This unit presents two strategies for protein expression using SFV vectors. In both cases the protein‐coding sequence of interest is cloned into a plasmid vector, which is subsequently. The structure of the particle formed by the SFVmSQL mutant of Semliki Forest virus (SFV) has been defined by cryo-electron microscopy and image reconstruction to a resolution of 21 A.

Book Title. eLS. Additional Information. How to Cite. Sjöberg, M. Semliki Forest Virus Expression System. eLS. Author Information. Karolinska Institute, Huddinge, Sweden. Based in part on the previous version of this eLS article ‘Semliki Forest Virus Expression System’.

Note: The images also appear when selecting from individual virus names. While these images were used as illustrations at the +Strand RNA virus meeting, they span a wide range of RNA/DNA as either single strand or double strand.

Most of these images are x pixels and saved qith Quality 12 (Maximum) from Photoshop. The course of Semliki Forest virus (SFV) A7(74) infection in immunocompetent BALB/c, athymic nu/nu and severe combined immunodeficient (SCID) mice was compared. BALB/c mice remained healthy and exhibited transient viraemia and infectious virus in the brain from days 2 to 7.

Antibodies were detectable by day 5. In comparison, SCID mice displayed a high incidence of paralysis and died: the. A procedure for the mobilization of Semliki Forest virus (SFV)-derived replicons using virus-like particles (VLPs) has been recently proposed.

VLPs were obtained from T cells co-expressing the vesicular stomatitis virus glycoprotein (VSV-G) and a modified SFV replicon.

Advantages of SFV VLPs include improved safety with a lack of sequence homology between components and reducing the risk of.The pathogenicity of the avirulent, demyelinating A7 strain of Semliki Forest virus (SFV) and the virulent SFV4 strain (derived from an infectious clone) for the central nervous system of adult BALB/c mice following intranasal infection was compared.

The techniques used included immunocytochemistry using anti‐SFV antibody and antibodies to.—Barmah Forest virus is identified as causing human disease in Australia.

—Scientists solved the crystal structure of the glycoprotein shell of the Semliki Forest virus. –—Large epidemic of the chikungunya virus on the island of La Réunion and the surrounding islands in the Indian Ocean.